Progesterone is a hormone naturally produced by the body that helps regulate the reproductive system and balance the effects of estrogen on the uterine lining.

For patients with a uterus who use systemic estrogen, progesterone is commonly prescribed to help prevent excessive thickening of the uterine lining. This is one of its most important roles in menopause hormone therapy.

Oral progesterone also produces metabolites that interact with pathways involved in relaxation and sleep, which is why it is frequently taken in the evening when prescribed that way.

Depending on why progesterone is prescribed, treatment may help support:

• Healthy uterine lining
• Balanced estrogen therapy
• More predictable bleeding patterns
• Sleep quality and nighttime relaxation
• Overall hormone balance
• Individualized menopause symptom management

Your provider may adjust the dose or schedule as your hormone plan changes.

Your provider will review your medical history, medications, hormone therapy, and treatment goals.

Discuss any history of unexplained vaginal bleeding, breast or hormone-sensitive cancer, liver disease, blood clots, pregnancy, or medication allergies. Progesterone can cause drowsiness or dizziness, so follow your prescribed timing carefully.

Prescription required.