Estradiol Cream
WHAT IT IS
A localized estradiol cream designed to support vaginal comfort and tissue health during perimenopause and menopause.
BEST FOR
Vaginal dryness • Irritation & discomfort • Painful intimacy • Vulvar comfort • Urinary symptoms associated with menopause • Vaginal tissue support
HOW IT'S USED
Applied vaginally as prescribed • Amount and frequency are personalized by your provider
WHY CHOOSE IT
A targeted estrogen option designed to address vaginal and urinary menopause symptoms directly where support is needed.
$ 149.00 USD
$ 129.00 USD
Personalized estrogen support in a simple topical cream.
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Description
Molecular Profile
Estradiol (E2)
Chemical formula C₁₈H₂₄O₂
Class Endogenous steroid hormone (natural, not synthetic)
Molecular weight ≈ 272.4 g/mol
Common esters Estradiol Valerate Estradiol Cypionate Micronized oral Transdermal patch Transdermal gel
Half-life Varies by form — hours (oral) to days (injectable esters)
Origin Produced endogenously via aromatization of testosterone by the enzyme aromatase, primarily in the ovaries, and in smaller amounts in fat, brain, and other tissue in all sexes
HOW IT WORKS

Estrogen helps maintain the thickness, elasticity, moisture, and overall health of vaginal and urinary tissues.

As estrogen levels decline during menopause, these tissues can become thinner, drier, and more sensitive, which may contribute to dryness, burning, irritation, discomfort during intimacy, and urinary symptoms.

Estradiol Vaginal Cream delivers estrogen directly to the vaginal tissues to help restore estrogen activity and support healthier, more comfortable tissue.

WHAT TO EXPECT

With consistent use as prescribed, estradiol vaginal therapy may help support:

• Improved vaginal moisture
• Less dryness and irritation
• Improved vaginal and vulvar comfort
• More comfortable intimacy
• Healthier vaginal tissue
• Improvement in some menopause-related urinary symptoms

Improvement is usually gradual, and your provider may adjust the frequency of use based on your response.

BEFORE YOU START

Before beginning vaginal estradiol, your provider will review your medical history, medications, menopause symptoms, and treatment goals.

Be sure to discuss any history of breast or other estrogen-sensitive cancers, unexplained vaginal bleeding, blood clots, stroke, liver disease, or pregnancy.

Your provider will determine whether vaginal estradiol is appropriate for you and how often it should be used.

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